Outbreak
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When people move into or change an environment, microbes that cause illness can "jump" from wildlife to humans and cause disease outbreaks that can spread internationally. Tracking down and responding to these outbreaks requires coordinated detective work from people in many professions.
Date Posted: Date the investigation is posted to the table. This happens once CORE begins to actively coordinate an investigation. In collaboration with federal and state partners, CORE initiates response activities to control the outbreak or adverse events.
Total Case Count: Updated weekly. For outbreak investigations, the case count is provided to the FDA by the CDC. Case counts are dynamic and the exact number of illnesses constantly changes during an investigation. This number is provided in order to provide an estimate of the size of an outbreak each week. In the case of adverse event investigations, FDA will provide the number of adverse events that have been self-reported by consumers to FDA consumer complaint coordinators and the CFSAN Adverse Event Reporting System (CAERS), which could include duplicate reports. More formalized data will be published in CDC Investigation Notices or in FDA and CDC advisories, should they be posted.
The FDA, along with CDC and state and local partners, investigated a multistate outbreak of Salmonella Senftenberg infections linked to certain Jif brand peanut butter products produced at the J.M. Smucker Company facility in Lexington, Kentucky.
The FDA, along with CDC and state and local partners, are investigating a multistate outbreak of Salmonella Senftenberg infections linked to certain Jif brand peanut butter products produced at the J.M. Smucker Company facility in Lexington, Kentucky.
During surges, state and local public health agencies may focus outbreak investigation resources on six populations identified as being at greatest risk of adverse outcomes or significant disruptions due to COVID-19. At-risk populations include healthcare, correctional settings, highly mobile populations, schools, critical infrastructure, and tribes and Native communities.
SummaryThe Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory about infections with an extensively drug-resistant strain of Verona Integron-mediated Metallo-β-lactamase (VIM) and Guiana-Extended Spectrum-β-Lactamase (GES)-producing carbapenem-resistant Pseudomonas aeruginosa (VIM-GES-CRPA) in 12 states. Most patients reported using artificial tears. Patients reported more than 10 different brands of artificial tears, and some patients used multiple brands. The majority of patients who used artificial tears reported using EzriCare Artificial Tears, a preservative-free, over-the-counter product packaged in multidose bottles. CDC laboratory testing identified the presence of the outbreak strain in opened EzriCare bottles with different lot numbers collected from two states. Patients and healthcare providers should immediately discontinue using EzriCare artificial tears pending additional guidance from CDC and the Food and Drug Administration (FDA).
Isolates in this outbreak are sequence type (ST) 1203, harbor blaVIM-80 and blaGES-9 (a combination not previously observed in the United States) and are closely related based on analysis of whole genome sequencing (WGS) data. These isolates are not susceptible to cefepime, ceftazidime, piperacillin-tazobactam, aztreonam, carbapenems, ceftazidime-avibactam, ceftolozane-tazobactam, fluoroquinolones, polymyxins, amikacin, gentamicin, and tobramycin; the subset of isolates that underwent antimicrobial susceptibility testing for cefiderocol were susceptible to this agent.
Review of common exposures revealed that most patients, including most patients with eye infections, used artificial tears prior to identification of VIM-GES-CRPA infection or colonization. Patients reported more than 10 brands of artificial tears, and some patients used multiple bran